you hav eto play two pair very cautiously, in general. the only times that i am particularly agressive with 2 pair is when i have top two, and there are no straight or flush possibilities out there.
in addition, you have to think about the low half of the pot. if you have the low locked up, then your two pair is dfinitely worth betting. but if you are betting your two pair whehn there is a low possible, and you dont have the low, you are just throwing away money.
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