I'm not shabi, but hopefully my 2 cents will count for something here too.
Yes, there is a huge difference. It's not just aggressiveness PREFLOP, as you suggested, but aggressiveness throughout the entire hand. You also need to lower your starting hand requirements quite a bit from what you would play full ring, obviously.
As for where the money is to be made.... keep this in mind, if you make 2 BB/100 playing both full ring and 6 max, you're going to be making a LOT more money by playing 6 max, because you get a lot more hands in per hour.
No one can tell you where there is more money to be made though, of course. In the end, poker is a zero sum game (minus the rake), so it depends on where you play better. I can tell you though that 6 max has significantly higher variance than full ring, so I'd recommend a bigger bankroll for it.
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